AARP Hearing Center
High Blood Pressure Guide
- Symptoms, causes and tests
- Stages and types
- Treatment and prevention
- High blood pressure myths
- Alcohol and blood pressure
- Hypertension headache myths
- Smoking and high blood pressure
- Anxiety, stress and hypertension
- Is hypertension genetic?
- Medications that raise blood pressure
- Home blood pressure monitoring
- Surprising causes of hypertension
Nearly half of all adults and close to 3 out of 4 people 60 and older, have high blood pressure, or readings of 130/80 mm Hg or higher, according to the American Heart Association. (Readings of 140/90 or higher is classified as stage 2 hypertension.) That’s about 120 million people at risk of heart disease; stroke; damage to the kidneys, brain and/or eyes; or even premature death from hypertension. And yet research, including a study published in 2025 in the journal Hypertension, shows that a growing number of adults are filling prescriptions for drugs that can raise blood pressure while simultaneously filling prescriptions for antihypertensive drugs.
An analysis of National Health and Nutrition Examination Survey (NHANES) data from 2009-2018 showed that 18 percent of U.S. adults with hypertension reported taking medications (other than those they take for their blood pressure) that may cause elevated blood pressure. The study of more than 27,500 adults, published in JAMA Internal Medicine, also found that nearly 15 percent of all adults — not just those with high blood pressure — were doing the same. Equally troubling: Health care providers may not always realize that meds taken for other conditions can push blood pressure higher and blunt the effects of antihypertensive therapy.
What medications should be avoided if you have high blood pressure?
The list is long. In a recent study in The Journal of Clinical Hypertension, researchers examined more than 200,000 reports from the Food and Drug Administration’s Adverse Event Reporting System and found that there are dozens of medications linked to high blood pressure. Those include:
Pain relievers and migraine treatments
Anyone with hypertension should be careful in reaching for over-the-counter (OTC) pain medications, particularly nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen. The American Heart Association advises that NSAIDs increase the risk of a heart attack or stroke with high doses of prolonged use. Additionally, people who have cardiovascular disease are at even greater risk.
Prescription NSAID drugs, such as indomethacin, which is used to relieve arthritis pain, can cause sodium retention as a side effect. This can reduce the effectiveness of blood pressure–reducing prescription drugs.
Triptans are among the most commonly prescribed medications for acute migraine headache relief. Because triptans tighten blood vessels (called vasoconstriction), which can increase blood pressure, they are not recommended for people with uncontrolled hypertension and related conditions. Calcitonin gene-related peptide monoclonal antibodies are injectable drugs for migraine relief; the FDA prescribing information notes post-marketing reports have described cases of new-onset hypertension and worsening preexisting hypertension in some patients taking CGRP. A review of research, published in 2025 in Cureus, however, suggests that the overall risk is modest, noting that patients with preexisting hypertension may be at higher risk than those without high blood pressure.
“This doesn’t mean that people with migraine who have hypertension shouldn’t take these types of medication, but if they do they should monitor their blood pressure,” says Dr. Morris Levin, a professor of neurology at the University of California San Francisco and chief of its Division of Headache Medicine. “A number of other prescription medications designed to prevent migraines can lower blood pressure. These include beta-blockers, calcium channel blockers and angiotensin receptor blockers.”
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