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Medications and Supplements to Avoid if You Have High Blood Pressure

You may be surprised at the everyday drugs and supplements that can raise your blood pressure


illustration of a clear tube bent into the shape of a heart showing medicine pills falling down into it
Nick Ferrari

Nearly half of all adults and close to 3 out of 4 people 60 and older, have high blood pressure, or readings of 130/80 mm Hg or higher, according to the American Heart Association. (Readings of 140/90 or higher is classified as stage 2 hypertension.) That’s about 120 million people at risk of heart disease; stroke; damage to the kidneys, brain and/or eyes; or even premature death from hypertension. And yet research, including a study published in 2025 in the journal Hypertension, shows that a growing number of adults are filling prescriptions for drugs that can raise blood pressure while simultaneously filling prescriptions for antihypertensive drugs. 

An analysis of National Health and Nutrition Examination Survey (NHANES) data from 2009-2018 showed that 18 percent of U.S. adults with hypertension reported taking medications (other than those they take for their blood pressure) that may cause elevated blood pressure. The study of more than 27,500 adults, published in JAMA Internal Medicine, also found that nearly 15 percent of all adults — not just those with high blood pressure — were doing the same. Equally troubling: Health care providers may not always realize that meds taken for other conditions can push blood pressure higher and blunt the effects of antihypertensive therapy.

What medications should be avoided if you have high blood pressure?

The list is long. In a recent study in The Journal of Clinical Hypertension, researchers examined more than 200,000 reports from the Food and Drug Administration’s Adverse Event Reporting System and found that there are dozens of medications linked to high blood pressure. Those include:

Pain relievers and migraine treatments

Anyone with hypertension should be careful in reaching for over-the-counter (OTC) pain medications, particularly nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen. The American Heart Association advises that NSAIDs increase the risk of a heart attack or stroke with high doses of prolonged use. Additionally, people who have cardiovascular disease are at even greater risk.

Prescription NSAID drugs, such as indomethacin, which is used to relieve arthritis pain, can cause sodium retention as a side effect. This can reduce the effectiveness of blood pressure–reducing prescription drugs.

Triptans are among the most commonly prescribed medications for acute migraine headache relief. Because triptans tighten blood vessels (called vasoconstriction), which can increase blood pressure, they are not recommended for people with uncontrolled hypertension and related conditions. Calcitonin gene-related peptide monoclonal antibodies are injectable drugs for migraine relief; the FDA prescribing information notes post-marketing reports have described cases of new-onset hypertension and worsening preexisting hypertension in some patients taking CGRP.  A review of research, published in 2025 in Cureus, however, suggests that the overall risk is modest, noting that patients with preexisting hypertension may be at higher risk than those without high blood pressure.

“This doesn’t mean that people with migraine who have hypertension shouldn’t take these types of medication, but if they do they should monitor their blood pressure,” says Dr. Morris Levin, a professor of neurology at the University of California San Francisco and chief of its Division of Headache Medicine. “A number of other prescription medications designed to prevent migraines can lower blood pressure. These include beta-blockers, calcium channel blockers and angiotensin receptor blockers.”

3 lifestyle habits that can increase blood pressure

Smoking

Smoking cigarettes raises blood pressure primarily because nicotine causes blood vessels to constrict and stimulates the release of stress hormones, which increases blood pressure, as well as heart rate. Over time, chemicals in tobacco smoke also damage the lining of arteries and promote plaque buildup, making blood vessels narrower and less flexible and increasing the risk of hypertension and heart disease, according to the American Heart Association.

Eating high-sodium foods

In a study of adults ages 50 to 75, published in JAMA in 2023, 75 percent of participants who followed a low-sodium diet (meaning less than 2,000–2,300 milligrams of per day, or about one teaspoon of salt) significantly lowered their blood pressure after just one week, compared with those who followed a high-sodium diet. Why? Sodium causes the body to retain water, increasing the volume of blood circulating through the blood vessels. That added fluid puts greater pressure on artery walls and forces the heart to work harder. Over time, that can contribute to the development of hypertension. Two easy ways to lower your sodium: Swap canned vegetables and frozen dinners with their fresh counterparts, and remove the saltshaker from the dinner table.

Drinking alcohol

Raising a glass—even one glass a day—can raise blood pressure by activating the sympathetic nervous system, which increases heart rate and constricts blood vessels. Alcohol can also stimulate hormones that cause the body to retain fluid and sodium, further increasing pressure within the arteries, suggests a study published in Hypertension. Research published in 2025 in the journal Circulation recommends no more than one drink per day for women, and two or less per day for men.

Decongestants

If you have wondered why many nasal decongestants are located in the restricted-access section of pharmacies, here’s one reason: Many of them include a recommendation to ask a doctor before use if you have a history of high blood pressure or heart disease, among other conditions.

The primary ingredients in many OTC decongestants constrict blood vessels in the nose and sinuses. Unfortunately, they also tighten blood vessels throughout the body, which may cause a marked rise in blood pressure in people with severe or uncontrolled hypertension.

Amphetamines, stimulants

Amphetamine, a psychomotor stimulant prescribed for attention deficit hyperactivity disorder, sleep disorders and sometimes obesity is a drug that can rapidly and acutely increase blood pressure by stimulating the nervous system and constricting blood vessels. Using stimulants such as amphetamines or cocaine can lead to dangerous spikes in blood pressure; accelerated hypertension is a well-known complication of recreational stimulant use.

Corticosteroids

Oral steroids, a form of corticosteroids, are used in the management and treatment of numerous medical disorders. They help reduce inflammation and suppress the immune system by reducing the chemicals that cause inflammation and reducing immune system activity by affecting the way that blood cells work. Steroids are prescribed to treat rheumatoid arthritis, gout, lupus, asthma, allergic rhinitis, hives, inflammatory disorders, allergic and autoimmune diseases, inflammatory bowel disease, neurological disorders, prevention of graft and/or organ rejection, and skin disorders.

Unfortunately, steroids can cause or exacerbate hypertension, especially when used in high doses for more than two weeks. Corticosteroids like prednisone can cause the body to retain sodium and water and lose potassium, which can lead to fluid retention, weight gain and/or bloating, elevating blood pressure. People with risk factors for high or borderline high blood pressure may be more likely to develop the condition while taking prednisone.

People with uncontrolled hypertension should not take corticosteroids if at all possible, and patients currently on corticosteroids should talk with their providers about alternatives. Individuals taking high-dose corticosteroids for an extended period should monitor their blood pressure at least once a month after initiating this therapy.

Yohimbine, which can be prescribed alongside a primary treatment for sexual function, should not be taken by men who have been diagnosed with or are at risk for hypertension.

Which supplements to avoid if you have high blood pressure

Herbal supplements are natural. But are they safe? Three in particular should be avoided.

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St. John’s Wort

St. John’s wort is associated with increased blood pressure and rapid heartbeat. It can cause serious and potentially dangerous interactions with multiple drugs and impact their effectiveness. St. John’s wort should not be taken with antidepressants such as selective serotonin reuptake inhibitors (SSRIs). Mixing the two can trigger serotonin syndrome, a potentially life-threatening condition that may cause high blood pressure and a rapid heartbeat, among other symptom.

Licorice root

Consuming large amounts of licorice root over a period of days to weeks can cause severe side effects, including heart attacks. The National Center for Complementary and Integrative Health advises that consuming excessive amounts of licorice root or for long periods of time may pose particular risks for people with hypertension.

Ginseng

The relationship between blood pressure and ginseng is a little murky. The herbal supplement used in traditional Chinese medicine for centuries may interact with certain medications, such as calcium channel blockers and other high blood pressure medications, as well as statin medications and some antidepressants. Studies on the effect of Asian ginseng on the blood thinner warfarin (Coumadin) are inconclusive. If you’re taking medication, the American Heart Association recommends talking with your health care provider before using Asian ginseng.

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How to avoid taking medications that raise blood pressure

  • Search PIMsPlus (www.pimsplus.org), a database of prescription and OTC medications that older adults should use with caution because the potential risk of adverse effects may outweigh the benefit. The database was developed and is regularly updated by eldercare pharmacy specialists.
  • Provide complete medication information, including OTC meds and supplements, to each of your physicians. Patients who see multiple physicians should not assume each doctor knows what the others are doing. Communication among medical providers is a good way to determine if alternate treatments are necessary. If direct communication isn’t possible, try to bring medical records to doctor visits or request that electronic medical records be shared between providers. Most medical centers and clinics have electronic medical records; however, medication lists depend on clinic staff or physicians to enter in your medications—generic or brand name, dose, frequency of dosing, date started and reason for your taking it.
  • You should prepare a written list of all medications, vitamins, supplements you are using, and the information and bring it with you to all medical appointments to allow the clinic staff and providers to review this in comparison to the list in your electronic medical record
  • Use a single pharmacy whenever possible, and get to know your pharmacist. If you use multiple pharmacies, make sure that each one has a record of all your drugs, even those given to you as samples. That way, pharmacists will automatically be alerted if the prescription you’re looking to fill may be inappropriate for your drug regimen.

“If you take drugs for multiple health issues, such as hypertension, arthritis and diabetes, consultation with an ‘age-friendly’ pharmacist may be beneficial,” advises Chad Worz, a pharmacist and CEO of the American Society of Consultant Pharmacists (ASCP). “They will evaluate all the medications that a person is taking to try to ensure appropriate, effective and safe use.”

As advocates for older adults, these pharmacists follow what’s known as the 4Ms of the age-friendly movement: What Matters, Medications, Mentation and Mobility. “They specialize in identifying, resolving and preventing problems related to medications and ensure they fit with what is important to the individual and their lifestyle,” says Worz. “If changes are needed — providing an alternative drug, prescribing a lower dosage or discontinuing a drug altogether because its purpose is being met by another medication — older adult-care pharmacists will also notify a patient’s primary care physician of their findings and recommendations. They collaborate with PCPs to identify the best medication mix to achieve results and improve quality of life.”

At a Glance: Medications That Can Impact Blood Pressure

Pain

  • Nonsteroidal anti-inflammatory drugs (NSAIDs):
    • Ibuprofen (Advil, Genpril, IBU, Midol IB, Motrin IB, Proprinal)
    • Naproxen (Aleve, EC-Naprosyn, Flanax, Naprelan, Naprosyn, Anaprox, Anaprox-DS, naproxen sodium)
    • Indomethacin (Indocin) Piroxicam (Feldene)

Migraine Headache Medications

Triptans

  • Almotriptan (Axert)
  • Eletriptan (Relpax)
  • Frovatriptan (Frova)
  • Naratriptan (formerly Amerge)
  • Rizatriptan (Maxalt, Maxalt-MLT)
  • Sumatriptan (Imitrex, Zembrace SymTouch)
  • Zolmitriptan (Zomig)

CGRP monoclonal antibodies

  • Erenumab (Aimovig)
  • Fremanezumab (Ajovy)
  • Galcanezumab (Emgality)

Decongestants

  • Pseudoephedrine (Sudafed)
  • Phenylephrine (Nasop, Sudafed PE, Neo-Synephrine, Ah-Chew D, Despec-SF, Biorphen, Lusonal, Triaminic, Phenyl-T, Vazculep)
  • Naphazoline
  • Oxymetazoline (Afrin)
  • Ephedrine (Primatene)

Psychostimulants

  • Amphetamine (Adzenys, Dyanavel XR, Evekeo)
  • Amphetamine and dextroamphetamine (Adderall, Mydayis)
  • Methylphenidate (Ritalin, Adhansia XR, Aptensio XR, Concerta, Cotempla XR-ODT, Jornay PM, Metadate ER, Methylin, QuilliChew ER)

Corticosteroids

  • Prednisone (Deltasone, Prednicot, Rayos, Sterapred)
  • Methylprednisolone (Medrol, Methylpred-DP)
  • Dexamethasone (Decadron, DexPak 6 Day Taperpak, Hemady)

Immunosuppressants

  • Cyclosporine (Gengraf, Neoral, Sandimmune)
  • Tacrolimus

Weight loss medications

  • Benzphetamine (Regimex, Didrex)
  • Diethylpropion (Tenuate, Tenuate Dospan)
  • Phendimetrazine (Bontril, Melfiat)

At a Glance: Medications That Can Impact Blood Pressure

Pain

  • Nonsteroidal anti-inflammatory drugs (NSAIDs):
    • Ibuprofen (Advil, Genpril, IBU, Midol IB, Motrin IB, Proprinal)
    • Naproxen (Aleve, EC-Naprosyn, Flanax, Naprelan, Naprosyn, Anaprox, Anaprox-DS, naproxen sodium)
    • Indomethacin (Indocin) Piroxicam (Feldene)

Migraine Headache Medications

Triptans

  • Almotriptan (Axert)
  • Eletriptan (Relpax)
  • Frovatriptan (Frova)
  • Naratriptan (formerly Amerge)
  • Rizatriptan (Maxalt, Maxalt-MLT)
  • Sumatriptan (Imitrex, Zembrace SymTouch)
  • Zolmitriptan (Zomig)

CGRP monoclonal antibodies

  • Erenumab (Aimovig)
  • Fremanezumab (Ajovy)
  • Galcanezumab (Emgality)

Decongestants

  • Pseudoephedrine (Sudafed)
  • Phenylephrine (Nasop, Sudafed PE, Neo-Synephrine, Ah-Chew D, Despec-SF, Biorphen, Lusonal, Triaminic, Phenyl-T, Vazculep)
  • Naphazoline
  • Oxymetazoline (Afrin)
  • Ephedrine (Primatene)

Psychostimulants

  • Amphetamine (Adzenys, Dyanavel XR, Evekeo)
  • Amphetamine and dextroamphetamine (Adderall, Mydayis)
  • Methylphenidate (Ritalin, Adhansia XR, Aptensio XR, Concerta, Cotempla XR-ODT, Jornay PM, Metadate ER, Methylin, QuilliChew ER)

Corticosteroids

  • Prednisone (Deltasone, Prednicot, Rayos, Sterapred)
  • Methylprednisolone (Medrol, Methylpred-DP)
  • Dexamethasone (Decadron, DexPak 6 Day Taperpak, Hemady)

Immunosuppressants

  • Cyclosporine (Gengraf, Neoral, Sandimmune)
  • Tacrolimus

Weight loss medications

  • Benzphetamine (Regimex, Didrex)
  • Diethylpropion (Tenuate, Tenuate Dospan)
  • Phendimetrazine (Bontril, Melfiat)

A Guide to High Blood Pressure 

Discover the risk factors, diagnostic process and potential symptoms of hypertension

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