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‘Pirola’ COVID Variant Spreads Quickly in U.S.

Cases caused by the BA.2.86 strain have tripled in just days

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A highly mutated coronavirus variant that a few months ago was responsible for only a few COVID-19 infections in the U.S. is gaining traction, new data shows.

According to the Centers for Disease Control and Prevention (CDC), BA.2.86 (nicknamed “Pirola” on social media) now accounts for roughly 9 percent of cases in the U.S., up from 1.3 percent last month and 3 percent two weeks ago.

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In some areas of the country, that share is larger; BA.2.86 is behind more than 13 percent of cases in the Northeast, for example, and the CDC says its presence is only expected to increase, according to an update the agency posted on Nov. 27.

However, despite its recent growth, health officials are not sounding the alarm just yet on the newly classified “variant of interest.” Both the CDC and World Health Organization (WHO) say the public health risk posed by BA.2.86 is low at this time, based on the available evidence. What’s more, it’s expected that existing vaccines, treatments and tests will continue to work.

What put BA.2.86 ‘high on radar screen’?

BA.2.86 first grabbed the attention of health experts across the globe in late August due to a striking number of genetic differences that set it apart from previous versions of the virus.

All viruses change over time, including the one that causes COVID-19. These changes can affect how contagious a virus is or how well it responds to treatment, according to the CDC, which is why scientists keep close tabs on the coronavirus’ evolution.

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What first concerned scientists about BA.2.86, however, is that it has a lot of changes — there are more than 35 mutations relative to the omicron strains that have recently been circulating. According to the CDC, that’s a difference that is more in line with those seen between the initial omicron variant and its predecessor, delta.

The location of these mutations also warranted a closer look, Andy Pekosz, a professor of microbiology at Johns Hopkins Bloomberg School of Public Health, told AARP in August. “A lot of those mutations are in areas where we know antibodies bind to the spike protein,” which is what the virus uses to enter our cells, he said. “So that’s why that variant is really high on our radar screen.”

Since the CDC’s initial risk assessment of BA.2.86 in August, however, the variant remained relatively uncommon in the U.S. It only started picking up steam in mid-October.

Vaccines, tests and treatments for Pirola variant

While it’s too soon to know whether BA.2.86 causes different symptoms from other circulating coronavirus variants, the CDC says it expects our current treatments and tests will remain effective.

What’s more, the CDC says the most recently updated COVID-19 vaccines “are expected to increase protection against BA.2.86, as they do for other variants.”


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Vaccine uptake, however, has been low since the latest shots became available in September. As of mid-October, 7 percent of Americans in a national survey reported getting the vaccine.

“We need to really, really emphasize that you need to keep re-upping your vaccines to stay well protected,” says Camille Kotton, M.D., clinical director for transplant and immunocompromised host infectious diseases at Massachusetts General Hospital in Boston. “Especially with some of the new emerging variants, there’s no time like the present.”

A few other measures can help protect you from the virus this winter, health experts say. With COVID-19 hospitalizations and deaths ticking up, consider wearing a mask again in crowded indoor areas if you have stopped, Pekosz said. Last week about 18,000 people in the U.S. were hospitalized with COVID-19, and deaths are up 8.3 percent in recent weeks.

“If you want to protect yourself, masks are one of the things that you can do if you’re in that highly vulnerable population,” Pekosz added.

It’s also a good time to check your stock of COVID tests, so that if you come down with symptoms, you’ll have some on hand. The government announced on Nov. 20 that each U.S. household can order four more at-home tests for free. If you missed out on ordering four in the fall, you can order eight this go-round.

If you test positive for COVID-19, you may be eligible for antiviral treatments including Paxlovid, which can help keep a mild infection from turning more severe.

“Now’s not the time to panic or to fear the worst,” Pekosz said. “Now’s the time to really sort of say, ‘What would I do if I was positive for COVID?’ ” And have a plan in place.

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