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In 2004, a team of researchers at Rush University Medical Center enlisted a group of older adults who were participating in the ongoing Rush Memory and Aging Project (MAP) for a spin-off study. MAP began in 1997 with the goal of pinpointing the factors associated with memory loss in older adults, with an emphasis on Alzheimer’s disease, the most common cause of dementia.
Researchers now wanted to zero in on diet; specifically, the effects of certain foods and nutrients as a preventive measure against Alzheimer’s. Using past research, they developed a MIND diet score partially based on the Mediterranean and DASH (Dietary Approaches to Stop Hypertension) diets, both of which have been shown to benefit brain health.
For nine years, participants agreed to keep track of what they ate and then fill out a dietary questionnaire at an annual cognitive assessment. At the end of that period, researchers found that participants with the highest MIND diet scores had a significantly slower rate of cognitive decline, compared with those who had the lowest scores.
Those initial findings, which were reviewed in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, provided the basis for the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet.
More than 10 years later, research continues to show the cognitive benefits of following the MIND diet. In one study of people ages 45 to 75, published in May 2025 in Current Developments in Nutrition, participants who closely followed the MIND diet were significantly less likely to develop dementia than those who didn’t adhere to the plan.
What Do You Eat on MIND?
Eat From 9 Food Groups:
- Leafy green vegetables: at least six servings per week
- Other vegetables: at least one serving per day
- Berries: at least two servings per week
- Whole grains: at least three servings per day
- Fish: one serving per week
- Poultry: two servings per week
- Beans: four servings per week
- Nuts: five servings per week
- Extra virgin olive oil: two tablespoons a day
And Avoid These 5 Food Types
- Red meat
- Pastries and sweets
- Cheese
- Butter/margarine
- Fast/fried food
Source: Harvard T.H. Chan School of Public Health
A greater adherence to the MIND diet was also found to be associated with slower brain shrinkage and gray matter loss, corresponding with an 8 to 20 percent reduction in age-related changes, according to a recent study published in the Journal of Neurology, Neurosurgery & Psychiatry. The study examined over 1,600 middle-aged and older individuals from the Framingham Heart Study Offspring cohort over an average of 12 years.
What foods are allowed on the MIND diet?
Like the Mediterranean and DASH diets, the MIND eating plan is made up of plant-based foods and limits the intake of foods high in saturated fat. Unlike these diets, though, MIND specifies 10 “brain healthy” food groups to eat — among them, vegetables, berries, olive oil, nuts, whole grains and beans — and five unhealthy foods to limit (red meat, fast and fried foods, pastries, cheese and other sweets).
“The MIND diet would be most appealing to those who want to focus on brain health as they age,” Liz Weinandy, an outpatient dietitian and clinical instructor at Ohio State University’s Wexner Medical Center. “If you have a family history of Alzheimer’s or dementia, this diet may be especially attractive.”
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