4 Warning Signs of Melanoma That Are Easy to Miss

2. ‘Where the sun doesn’t shine’

The majority of melanomas are thought to be caused by ultraviolet (UV) light, but not all of them come from sun exposure. Melanoma can develop anywhere on the body, including “in places the sun doesn’t shine,” like the soles of the feet or the palms of the hand, says Elizabeth Quigley, M.D., a dermatologist and associate physician at Memorial Sloan Kettering Cancer Center in New York.

The cancer can also appear as a dark streak under a fingernail or toenail, which is what happened to musician Bob Marley. He initially mistook his melanoma for a bruise on the toe and eventually died from it. (A clue that you should see a doctor: If you discover a dark spot under the nail bed that doesn’t grow out with the nail over time, like a blood blister would, Buchbinder says it’s time to make an appointment.)

And while it’s rarer, melanoma also can develop on the eye, inside the mouth or on the scalp. Buchbinder has even seen patients experience changes in their hair color — “someone who had gray hair and developed a black streak” — because of a melanoma growing on the scalp. “So, strange things can happen, but these aren’t common ones,” she adds.

That said, these “hidden” melanomas are more common in people with darker skin, points out Vishal Patel, M.D., assistant professor of dermatology at the George Washington School of Medicine & Health Sciences and director of the cutaneous oncology program at the GW Cancer Center.

“I tell Black and Indian and Asian patients that if you have nail changes, [any dark spots] on your palms and soles, as well as in the eye and mouth, these are ones that I worry about,” Patel says. “Because while it is less common to have that, when it does happen, it is worse. So, it’s important to know about that.”

Melanoma is 20 times more common in white individuals than in Black individuals, according to the American Cancer Society. Hispanics are also less likely than their white peers to get the skin cancer.

However, when melanoma develops in people of color, it’s often diagnosed at a later, more dangerous stage. A 2019 study from the Centers for Disease Control and Prevention (CDC) found that the five-year melanoma survival rate among non-Hispanic Black populations was 66.2 percent, compared with 90.1 percent for non-Hispanic white populations.

3. Red, white and blue hues

Melanomas are often depicted as dark-brown moles, but they can actually present in a variety of colors. The cancer may have a blue tint to it, from deeper pigmentation, says professor Robert Brodell, M.D., chair of the Department of Dermatology at the University of Mississippi Medical Center. Or it can appear red, the result of an immune response. “The body is attacking it. It knows it’s abnormal and it’s trying to defend itself, and you get inflammation,” Brodell explains.

It’s also possible for a melanoma to “look like a rash,” Quigley says, and to take on a pink hue. But when the spot doesn’t get better with creams and other treatments that normally nix a rash, “you need to check and make sure that that’s not a skin cancer,” she adds.

Another sign of a melanoma can be lack of color. Some of these cancerous spots lose their pigmentation completely or partially, leaving a halo of white around a darker spot.

“And that’s something that gives us a little concern,” Buchbinder says. “Was the body recognizing something like a melanoma that was going wrong, and in its process of destroying the melanoma, it destroyed some of the normal melanocytes [cells in the skin that produce pigment] in that area? It’s just one of those things that may kind of make you look a little closer at something.”

4. Spots on the skin that bleed or itch

If a mole on your body starts to itch or becomes more painful or tender, you need to get it checked out. The same goes if the surface of a mole changes — maybe it starts to ooze or bleed or take on a scalier appearance and doesn’t heal on its own.

“We think that some of that irritation — the itching, the bleeding — is actually the body starting to recognize [the cancer] and starting to attack it a little, making it irritated. That’s why you’ll see some itching and bleeding and irritation near the actual mole,” Buchbinder says.

Skin cancer prevention

Wearing sun-protective clothing, sporting UV-blocking sunglasses and lathering on sunscreen are some of the most effective ways to prevent melanoma.

Another thing to keep in mind: People on certain blood pressure medications — including diuretics such as hydrochlorothiazide and calcium channel blockers such as nifedipine — need to be extra cautious when spending time outside. “Many of those [blood pressure] medicines make us more sensitive to the sun and more likely to get a sunburn,” Quigley says, which amplifies the risk of skin cancer.

Not all skin cancers are caused by sun exposure, so frequent skin checks are an important part of prevention, too. Catching a melanoma before it has time to grow in thickness and spread to other areas of the body greatly improves your chances of survival. (You can find tips on how to do a self-exam on the American Cancer Society’s website.) Keeping your immune system as strong as possible can also help prevent melanoma.

The bottom line: “People need to really be aware of their skin,” Quigley says. “And if there’s anything that seems abnormal, it’s not the time to wait — it needs to be evaluated.”​

Editor's note: This article, originally July 9, 2021, has been updated to reflect new information.