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Dementia vs. Alzheimer’s: Which Is It?

How to understand the difference — and why it matters


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The terms “dementia” and “Alzheimer’s” have been around for more than a century, which means people have likely been mixing them up for that long, too. But knowing the difference is important.

In the simplest terms, one is broader than the other. If the two were nesting dolls, Alzheimer’s would fit inside dementia, but not the other way around. While Alzheimer’s disease is the most common form of dementia (accounting for an estimated 60 to 80 percent of cases), there are several other types.

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The second most common form is vascular dementia, which is caused by decreased blood flow to the brain. Other types of dementia include Lewy body dementia and frontotemporal dementia. In addition, certain medical conditions can cause serious memory problems that resemble dementia.

A correct diagnosis means the right medicines, remedies and support. It could also impact clinical trial eligibility and participation.

What it is

Dementia

In the simplest terms, dementia is a decline in mental function — thinking, remembering and reasoning — that is usually irreversible. It’s a syndrome, not a disease, notes neurologist Ron Petersen, M.D., director of the Mayo Clinic Alzheimer’s Disease Research Center and the Mayo Clinic Study of Aging in Rochester, Minnesota.

The catchall phrase encompasses several disorders that cause chronic memory loss, personality changes or impaired reasoning, Alzheimer’s disease being just one of them, says Dan G. Blazer, M.D., a psychiatrist and professor emeritus at Duke University School of Medicine.

To be called dementia, the disorder must be severe enough to interfere with your daily life, says psychiatrist Constantine George Lyketsos, M.D., director of the Johns Hopkins Memory and Alzheimer’s Treatment Center in Baltimore.

What it’s not? Typical mild forgetfulness that sometimes accompanies aging — say, having trouble remembering the name of an acquaintance who comes up to you on the street.

In fact, the earliest stage of dementia, known as mild cognitive impairment (MCI), is considered “forgetfulness beyond what is expected from aging,” Petersen says. With MCI, a person is still functioning normally — paying her bills, driving well enough, doing his taxes — though performing some of those tasks may take longer than they used to. When someone starts to need regular assistance to do such daily activities, “that gets into the dementia range,” Petersen says.

Alzheimer’s

Alzheimer’s is a specific brain disease that progressively and irreversibly destroys memory and thinking skills. Age is the biggest risk factor for the disease. Eventually, Alzheimer’s disease takes away the ability to carry out even the simplest tasks.

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To help determine whether patients have this particular brain disease, doctors talk to the patients and their close family members about any recent challenges or changes in behavior or memory. They also administer a mental status exam in an office setting, and possibly do a short neuro-psych evaluation.

While a cure for Alzheimer’s remains elusive, researchers have made some progress when it comes to finding treatments that may be able to slow the progression of the disease. So far, two drugs have received accelerated approval from the Food and Drug Administration.

How it’s diagnosed

Dementia

A doctor must find that you have two cognitive or behavioral areas in decline to diagnose dementia. These areas are disorientation, disorganization, language impairment, mood change, personality change and memory loss. To make an evaluation, a doctor (often a specialist such as a psychiatrist, neurologist or geriatric medicine physician) typically takes a patient history and administers several mental-skill challenges.

Thanks to growing medical consensus that irritability, depression and anxiety often flag dementia before memory issues do (and official changes to the diagnostic criteria to reflect this), doctors also ask more about changes in mood or personality, Lyketsos notes.

To check for cognitive decline, a doctor will ask whether a patient is experiencing just forgetfulness or, potentially more indicative of dementia, also having trouble figuring out calculations such as a restaurant tip, Petersen says. A physical exam can be important for flagging something like specific types of dementia caused by vascular disease (strokes) or Parkinson’s disease.

Next, a standard and fairly brief round of memory and thinking tests is given in the same office visit. In the Hopkins Verbal Learning Test, for example, you try to memorize and then recall a list of 12 words — and a few similar words may be thrown in to challenge you. Another test — also used to evaluate driving skills — has you draw lines to connect a series of numbers and letters in a complicated sequence.

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Video: How I Discovered I Had Early-Onset Alzheimer's

Alzheimer’s

Doctors use several different methods to determine if an individual has Alzheimer’s disease, according to the National Institute on Aging. Physical and mental evaluations are often part of this process. Memory and problem-solving tests are also used.

With Alzheimer’s in particular, the progression and timing of symptoms is important. To identify this degenerative brain disease, doctors are looking for “a gradual, insidious onset that is slowly getting worse,” Petersen says.

Until fairly recently (before the early 2000s), a conclusive diagnosis was not possible until an autopsy was performed and the brain examined for the physical hallmarks of the disease — beta-amyloid and tau, proteins that look like plaques and tangles in the brain.

Now, a patient can get a PET scan or cerebrospinal fluid sampling that can show, with high accuracy, whether such plaques or tangles are present. But a high percentage of patients never get such a test, doctors say. For one, these tests are invasive. They’re also expensive and typically are not covered by insurance, though this could change in the future as more Alzheimer’s treatments become available.

Researchers are hopeful that faster, less-expensive tests will be available soon, like a blood test to diagnose the disease in the doctor’s office, or even to identify someone at high risk for developing Alzheimer’s.

Editor’s Note: This story, last edited on June 15, 2020, has been updated to include new information pertaining to Alzheimer’s treatments.

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