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High Blood Pressure Medication Side Effects: What You Should Know

Many drugs can cause issues, but it’s important to work with your doctor to keep your blood pressure in check

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AARP (Source: Shutterstock)

You’ve been told you have high blood pressure. You may have tried to lower it by reducing the salt in your diet and exercising. This has helped, but your readings are still too high, and your doctor has prescribed a medication. Your blood pressure now looks good, but the medication is making you feel lightheaded.  

You are not alone. Many medications used to lower blood pressure can cause side effects, especially in people who are older, which is the major reason people stop taking them. Common complaints are feeling lightheaded or fatigued.  

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Some people also only take medication when they “sense” that their blood pressure is high due to having symptoms such as a headache. This can be dangerous because most people have no symptoms when their blood pressure is elevated. That’s why it’s important to stay on your prescribed dosage and talk to your doctor about any concerns you have with the medications. 

A study published in the journal Hypertension reviewed high blood pressure treatment in adults age 60 and older in clinics across the United States from 2008 to 2018. Researchers found that only 30 percent of patients had reduced their blood pressure to the medically recommended levels during outpatient clinic visits. The authors did not have specific information on whether patients either stopped taking their medication or reduced their doses, but other studies suggest that one reason was concern for potential adverse side effects.

Hypertension can lead to profound health risks, especially for older adults. That’s why it’s so important to understand what your blood pressure numbers should be, what the options for treatment are, how you can work with your doctor to help you improve your blood pressure and how to avoid the side effects of blood pressure medications.

What is your blood pressure goal?  

Your blood pressure numbers are measured in millimeters of mercury (mm Hg). According to the 2017 American College of Cardiology and American Heart Association Guideline, normal blood pressure is less than 120/80, elevated is considered 120-129/less than 80, and hypertension is 130/80 or above. For older adults, the guideline states that a BP target greater than 130/80 mm Hg would be appropriate. While both numbers (top number — systolic, and bottom number — diastolic) are important, it is felt that in older patients, the systolic is much more important than the diastolic in determining a patient’s prognosis. 

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“While people over 80 years old are more likely to experience side effects [from medication], they also stand to gain the most from intensive blood pressure control through a proven reduction in strokes and heart attacks,” says Randall S. Stafford, M.D., a professor of medicine at Stanford University and an author of the 2017 guideline. He goes on to say that “this requires carefully balancing potential benefits and harms, rather than simply forgoing intensive treatment.”

Experts emphasize that care should be individualized. “As a general rule, the lower the blood pressure, the better, as this will reduce the risks of heart attack and strokes,” says James Sheppard, who researches hypertension in older people at the University of Oxford in England. “However, if an older person is prone to falling over, or experiencing dizzy spells, then it may be appropriate to reduce the amount of antihypertensive treatment they are taking and aim for a higher target, such as below 150 mm Hg.” 

Is lowering blood pressure in older persons safe and effective? 

A study published in the journal Circulation looked at older women and blood pressure ranges. “Our major finding was that in relatively healthy women ... aged 65 years or older, maintaining a systolic blood pressure below 130 mm Hg was associated with longevity,” or survival to age 90, says senior author Bernhard Haring, M.D.

Frailty is an important consideration for older people, especially when falls could lead to mobility issues. A sub-study of the SPRINT Trial, a large study on hypertension, published in Circulation, analyzed 9,306 older patients and found that 26.7 percent of them had frailty. Patients with frailty benefited similarly to other patients from intensive blood pressure control without an increased risk of serious adverse events. 

What are the barriers to blood pressure treatment in older adults?

As your body ages, how it metabolizes medications you take — called pharmacokinetics — also changes. This includes how medications are absorbed, processed and eliminated by your body. For instance, many drugs may stay in your system longer, increasing the risk of side effects.

Older adults often have other health problems requiring medications. Polypharmacy — having to take many medicines — can result in more side effects. Also, many people may already have problems with balance, fatigue or feeling dizzy, all which can be worsened by side effects from medications.

There can be many reasons for feeling lightheaded or having other symptoms, especially as you get older. It is important to speak with you doctor to make sure they are due to the blood pressure medications and no other causes. 

Jennifer Cluett, M.D., a hypertension specialist at Beth Israel Deaconess Medical Center in Boston, says it is important for patients to “have open, honest, nonjudgmental conversations” with their doctor about their medications, including whether they are taking them regularly and what side effects they are experiencing.

Do blood pressure medications make you feel tired?

People taking blood pressure medications may experience feelings of tiredness, fatigue and drowsiness. The main culprits are beta blockers, alpha-adrenergic blockers and centrally acting alpha adrenergic receptor agonists, although others can have these effects as well. (See the dropdowns below for details on specific high blood pressure medications and side effects.)

Why do these medications make you feel tired? It’s partly because of how these three classes of medications work. For example, beta blockers slow your heart rate. Alpha adrenergic medicines affect the central nervous system, including the sympathetic (“flight or fight”) system, which is involved in keeping us wakeful.

The lowering of blood pressure itself can cause feelings of fatigue. It may just take getting used to your new normal, and often the feelings resolve after giving your body time to adjust.

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Shutterstock / Roger Asbury

Can blood pressure medications cause lightheadedness?

When someone goes from sitting to standing, blood pools in the lower body and does not immediately return to the heart to be pumped out again. Normally, the body makes quick adjustments (such as increasing the heart rate) to correct for this. However, age and use of some medications for lowering blood pressure can affect your body’s ability to make these adjustments and cause what is known as orthostatic hypotension, the main symptom of which is lightheadedness. 

Check for orthostatic hypotension: Take your blood pressure while sitting, then recheck after standing. If your blood pressure drops by more than 20 points systolic or more than 10 points diastolic within three minutes after you stand, this may indicate you have orthostasis and may need to talk with your doctor about changing your medications or doses.

Other ways to reduce lightheadedness include:

  • Get up slowly from lying or sitting. 
  • Try waist-high compression stockings or an abdominal binder, which is a large compression belt that surrounds your abdomen and can help keep blood from pooling in your legs.
  • Keep well hydrated, especially in hot, humid weather.
  • Talk to your doctor about switching to blood pressure medications that are less likely to cause lightheadedness.

Cough due to ACEI Medications

ACEIs can cause what is generally a dry, tickly type of cough. The cough is a result of interactions between the ACEIs and substances your body makes.

  • It can happen soon after starting the medication or even weeks and months later.
  • The cough is generally not harmful and usually will go away after the medication is stopped.
  • One option is to switch to an ARB medication, which is much less likely to cause a cough.

Ankle swelling from Calcium Channel Blockers

This is a relatively common side effect, less so with the medications diltiazem and verapamil.

  • Lowering the dose may help.
  • Adding an ACEI or ARB may as well. Using a diuretic (unless needed for another medical reason) will not help because of the physiology that causes this kind of swelling.

Diuretics and urinary frequency

A common and very bothersome side effect of diuretic medications is having to run to the bathroom to urinate, which can start to occur within an hour of taking the medicine.  

  • If you take your diuretic once a day, take it in the morning to prevent having to get up during the night to go to the bathroom. 
  • If you have to go out, you may want to take it several hours before you leave, especially if you will not be near a bathroom.
  • If you take two a day, try to take one early in the morning and the second no later than about 4 p.m.
  • Shorter-acting diuretics (such as hydrochlorthiazide) tend to cause more urinary frequency than those that are longer acting (meaning the effect lasts longer in your body), such as chlorthalidone.        

Be careful about taking your medications in hot weather

In hot, and especially humid weather, you may be at greater risk for having side effects from high blood pressure medications.   

  • Stay hydrated. Clues that you might be dehydrated are loss of body weight, making less urine and producing urine that’s darker than usual. Be sure to check with your doctor if you have been put on fluid restriction.
  • Avoid alcohol, which can dehydrate you.

Specific Blood Pressure Medications and Their Side Effects

Many people can be started on one high blood pressure medication, or agent, but may require two or more if blood pressure remains high. It’s hard to say that one medication is better than another in terms of side effects, but individualizing your management plan based on what side effects you are susceptible to can help. The choice of medication may also depend on the need to treat other medical conditions, for example using a beta blocker for those with cardiovascular disease.  

Below is a list of commonly used blood pressure medications and their potential side effects. If you have concerns about any of the side effects, talk to your doctor about a potential alternative medication. It is important to not stop taking medication on your own, as this can cause your blood pressure to rise. 

The 2017 guideline lists the medications that are used for treating high blood pressure, divided into primary and secondary agents. For those in the primary group, there is more research showing that they reduce “clinical events,” meaning medical problems that may have resulted from hypertension. But that does not mean the other medications are not helpful, and your doctor may prescribe them for you.

Diuretics (water pills)

Examples:

  • Thiazide diuretics: chlorthalidone, hydrochlorothiazide, metolazone, indapamide
  • Other kinds of diuretics are considered secondary agents and include: furosemide, torsemide, bumetanide, spironolactone, eplerenone, triamterene and amiloride.

 

How they work:

Diuretics work by helping your kidneys flush out water and salt from your body.

 

Side effects:

  • Having to urinate frequently.
  • May cause your blood potassium and sodium levels to be low. (Exceptions are triamterene and amiloride.)
  • May increase skin sensitivity to the sun.
  • Infrequently cause headaches.
  • Hair loss (less common except with spironolactone)

 

Angiotensin-converting enzyme inhibitors (ACEI)

Examples:

  • Lisinopril, captopril, enalapril, fosinopril, ramipril.

 

How they work:

They inhibit your body from making a hormone called angiotensin II. Without this, your blood vessels can relax and dilate.

 

Side effects:

  • Dry cough (more common in women and those who are Asian)
  • Can cause your blood potassium levels to be too high.
  • Can worsen kidney function.
  • Infrequently can cause headache.
  • Rarely can cause angioedema, which is swelling that can happen anywhere in the body, including in your face, mouth, lips, throat and tongue, which can be a medical emergency.

 

Angiotensin II receptor blockers (ARBs)

 

Examples:

  • Valsartan, losartan, olmesartan, irbesartan, candesartan, telmisartan.

 

How they work:

They prevent angiotensin II, one of your body’s hormones, from constricting (narrowing) your blood vessels.

 

Side effects:

  • May push your potassium levels too high.
  • Can worsen kidney function.
  • Rarely cause cough and very rarely cause angioedema.



Calcium channel blockers (CCBs)

 

Examples:

  • Nifedipine, nicardipine, amlodipine, diltiazem and verapamil; they are generally not used to treat blood pressure unless you need this medication to treat another problem, such as atrial fibrillation (A-fib).

 

How they work:

They prevent calcium from entering the muscle cells in the walls of your arteries, which allows them to relax and dilate.

 

Side effects:

  • Ankle swelling, which is more common in women than men and is dose-related.
  • Diltiazem and verapamil slow heart rate.  

Beta blockers

  • These are generally used in patients who have another medical condition, such as cardiovascular disease.

 

Examples:

  • metoprolol, carvedilol, atenolol, bisoprolol, labetalol, nadolol

 

How they work:

  • They slow down your heart rate and reduce the force at which the heart pumps blood through your arteries.

 

Side effects:

  • Some people have fatigue, feelings of depression and decreased exercise tolerance.
  • Patients with pulmonary and reactive airway disease (such as asthma) may not tolerate beta blockers. 

 

Direct renin inhibitor

Example:

  • Aliskiren.

 

How they work:

  • They block a pathway in which your body makes angiotensin II, which constricts your arteries and results in raising your blood pressure.

 

Side effects:

  • Risk of high potassium, especially in people with kidney disease, GI disturbances (diarrhea) and cough. 

 

Alpha-adrenergic blockers

Examples:

  • Doxazosin, terazosin, prazosin.

 

How they work:

  • They reduce nerve impulses that constrict your arteries.

 

Side effects:

  • Fainting, dizziness, drowsiness, vertigo, headache, orthostatic hypotension. 

 

Centrally acting alpha adrenergic agonists

Examples:

  • Clonidine, methyldopa, guanfacine.

 

How they work:

  • They affect nerve impulses from your brain, allowing blood vessels to dilate.

 

Side effects:

  • Sedation, dry mouth, fatigue, orthostatic hypotension. 

 

Direct vasodilators

Examples:  

  • Hydralazine, minoxidil.

 

How they work:

  • They relax the muscles in blood vessel walls, allowing them to dilate.

 

Side effects:

  • May cause sodium and water retention.
  • Can increase your heart rate.
  • Minoxidil can cause hirsutism (hair growth, especially on the face in women).
  • Hydralazine can cause headache and a lupus-like syndrome.

At your doctor’s appointment:

  • Review your overall health status and any other medical problems.
  • Bring a list of all your medications, dosages and why you are taking each one.  Include nonprescription medications as well as vitamins, supplements, minerals and herbal preparations. Also note any drug allergies.

 

After starting a new medication:

  • Unless you have a serious reaction, try to give the new medication some time, say several days to a week, to see how you adjust to taking it.
  • It’s best not to stop any medication without first communicating with your doctor.
  • If you are not tolerating a higher dose, ask to take a lower dose. If your blood pressure levels are still too high, your doctor may add a medication from a different class.
  • And don’t forget about diet and exercise! Lifestyle changes can often lower the amount of blood pressure medication you need. 



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