What Your Eye Color Can Say About Your Health

What changes in eye color may mean for your health

If you notice any change in your eye color, you should always get it checked out by your eye doctor, Grover stresses. It can indicate a wide range of conditions, some benign, some potentially serious. They include:

1. A hazy blue or white ring that forms around your cornea

This condition, called arcus senilisis, is caused by a build-up of lipids, or fat, in your eye. Most older adults develop it, and it’s usually harmless, Grover says. But it can make your eyes appear a different color. Grover recalls patients brought in by younger relatives concerned that the patients’ brown eyes had turned blue. If you do notice this ring, it’s always good to let both your eye doctor and your primary care provider know, since it can be a sign of high cholesterol. 

2. Pigment loss

Certain eye conditions can cause your orbs to lose pigment over time, Grover says. One is pigmentary glaucoma, a condition where pigment rubs off of the back of your iris, raising eye pressure. It can also happen after cataract surgery: “If a lens is placed in the wrong position, it can cause pigment to be released into the eye,” Grover says. Both are treatable, so it’s very important to see your eye doctor if you notice any symptoms, such as halos or blurred vision.

3. Iris freckles

Just like you get freckles on your skin from sun exposure, you can also get them on your eye, Grover says. These are small brown spots on your iris that can make your eyes look like they’ve changed color. They’re harmless but should be checked out by an eye doctor. You can also develop iris nevi, which are dark growths on your eye that look like a mole and are in fact caused by the same pigment cells, called melanocytes. While most aren’t dangerous, they can raise your risk of developing eye cancer.

4. Red in the clear covering over your eye

Uveitis is an inflammation of the middle layer of your eyeball. It can be caused by an infection such as shingles, or from an inflammatory disease such as rheumatoid arthritis or lupus. Most often, it just makes your conjunctiva — the clear covering over your eye — look red, Grover says. But it can also make your eye color look different if the inflammation causes your iris to stick to your lens. If you notice any redness or eye color changes, accompanied by light sensitivity, blurry vision and/or seeing floaters, contact your eye doctor right away because uveitis can be serious; it can even lead to vision loss.

5. Large black pupils

If you’ve had a blow to the eye, damage to the iris can cause tissue loss that makes the eye appear as if it’s a different color. “If the trauma is bad enough, the pupil might stay dilated, which can make the eye appear black,” Silverstone says. If this happens, it’s very important that you see your doctor for medical treatment, and also to rule out another serious condition that could cause dilated pupils such as a brain injury or stroke.

6. Different-colored eyes caused by different pupil sizes

This very rare condition affects the eye and surrounding tissue on only one side of the face. It’s usually due to a stroke, tumor or spinal cord injury. One symptom is uneven pupil size, which can make it look like you have different-colored eyes, Grover says.

7. Clouding of the lens

Cataracts can cause a clouding of the eye lens that can make your eye look milky white, Silverstone says. About a quarter of people in their late 60s will have a cataract, and more than a third of people in their 70s, according to the National Eye Institute. Cataracts can easily be removed with surgery.

8. Brown eyes becoming darker, hazel eyes turning brown

If you have glaucoma, the first-line treatment is often a class of medications called prostaglandins that can change eye color. “It can make brown or hazel eyes turn more brown, or a darker shade of brown,” says Grover, who notes that it doesn’t usually cause color changes in blue or green eyes.  If you use the lash-growing prescription medication Latisse, you may notice these changes, too, Silverstone adds.

It’s important to remember that while your grandbaby’s eyes may have changed color from lighter to darker during the first year of life, as their body developed pigment, your eyes should stay constant. That’s why if you do notice any eye color changes, don’t panic, but do get them checked out.

Editor's note: This story, published Sept. 8, 2022, has been updated to reflect a new study.