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How Much Do You Know About Sjögren’s Disease?

Test your knowledge of this autoimmune illness


woman sitting on desk
It took years for Janet Church to receive a correct diagnosis of Sjögren's disease. She now works for the Sjögren's Foundation.
Ryan Donnell

This article was created with the assistance of generative AI. It was reviewed by editors before publication.

Question 1 of 8

Which glands are most commonly affected in Sjögren’s disease?

Sjögren’s primarily attacks the salivary and tear glands, reducing their ability to produce fluids. This results in hallmark symptoms: dry mouth and dry eyes. While other glands can be involved, these two are the most commonly affected.

Question 2 of 8

What is a serious long-term complication associated with Sjögren’s disease?

Sjögren’s increases the risk of lymphoma, a cancer of the lymphatic system. While the disease affects many body systems, this complication highlights its potential severity beyond dryness symptoms.

Question 3 of 8

What percentage of Sjögren’s patients are women?

Ninety percent of people diagnosed with Sjögren’s are women, though researchers are still unsure why. Hormonal or genetic factors may play a role, but this gender disparity is well established.

Question 4 of 8

Which of the following is NOT a common extraglandular symptom of Sjögren’s?

While Sjögren’s can affect many organs and systems, seizures are not listed as a common symptom. Extraglandular symptoms include fatigue, muscle or joint pain, GI issues, cough, rashes and nervous system issues such as numbness or dizziness.

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Question 5 of 8

Why is Sjögren’s often difficult to diagnose?

Sjögren’s is known for its slow development and mild early symptoms, such as dry mouth and fatigue, which many people ignore. This gradual progression and overlap with more common complaints make diagnosis challenging.

Question 6 of 8

What was Sjögren’s disease previously called?

Before being named after Henrik Sjögren, the condition was known as sicca complex syndrome or Mikulicz’s disease.

Question 7 of 8

What may be the likely cause of Sjögren’s, according to current understanding?

The cause is not fully known, but research points to a genetic predisposition, with environmental triggers activating an overactive immune response. A person must have the genes, and then something—possibly an infection or unknown environmental factor—activates them.

Question 8 of 8

What recent drug has received FDA breakthrough therapy designation for Sjögren’s?

Nipocalimab is a drug in phase 3 clinical trials that has received the FDA’s breakthrough therapy designation, which speeds up the review process due to its potential to significantly improve treatment for serious conditions like Sjögren’s.

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