How Many Times Can You Get COVID?

“It’s clear from the study of those coronaviruses, those cousins to COVID, that the protection you get after an infection wanes after a period of time,” says William Schaffner, M.D., a professor of preventive medicine and infectious diseases at Vanderbilt University School of Medicine. That’s why you can get repeated coronavirus-caused colds over the years. And it appears that the coronavirus that causes COVID-19 is “similar in that regard,” Schaffner says.

Reinfections tend to be milder in most

How long you’re protected from catching COVID-19 after already having had it — and how secure that protection is — is not well established, Schaffner says. “And it probably varies, depending upon which variant infected you.”

If you’re among the millions of Americans who have had COVID-19 caused by the omicron variant this winter or spring, you may be susceptible to another infection sooner than you think. “People with prior infection, even with [omicron subvariants] BA.1 or BA.2, are likely still at risk for BA.4 or BA.5,” CDC Director Rochelle Walensky said in a July 12 press briefing.

BA.5, another subvariant of omicron, is now the dominant variant circulating in the U.S., accounting for about 65 percent of COVID-19 cases; BA. 4, also part of the omicron family, is behind about 16 percent of COVID-19 cases in the U.S.

The good news: For many, repeat infections tend to be milder. Having already been acquainted with the virus, Adalja explains, the immune system is better able “to jump into action pretty quickly” and help keep the virus from taking hold.

That said, older adults, immunocompromised individuals and people with underlying conditions that can complicate a coronavirus infection “can still have serious disease” even if they’ve had COVID-19 before, Schaffner says, “because those people don’t respond optimally with their immune systems.”

Research is underway to learn whether certain people are more at risk for reinfection. So far, emerging data suggest that individuals who are vaccinated against SARS-CoV-2 and have had COVID-19 are better protected against reinfection than those with natural immunity or vaccination-derived immunity alone. Experts suspect that this so-called hybrid immunity generates a “broader spectrum of antibody response and a broader spectrum of immunity,” leading to a “more potent immune response,” says Alessandro Sette, a professor at La Jolla Institute for Immunology.

The CDC recommends that people who have had COVID-19 still get vaccinated for this “added protection.” And with BA.5 driving up new cases of COVID-19, as well as hospitalizations from the illness, health officials are urging adults 50 and older to get their second booster shot, if they haven’t already.

Another reason to get vaccinated even if you’ve had COVID-19: Data indicate that the rates of long COVID in vaccinated individuals who get a breakthrough infection “are roughly half of what they are in those who are unvaccinated,” says Peter Marks, M.D., director of the Food and Drug Administration (FDA) Center for Biologics Evaluation and Research. A new CDC report reveals that long COVID can affect about 1 in 5 COVID-19 survivors ages 18 to 64; 1 in 4 adults 65 and older are affected by new or lingering symptoms after a SARS-CoV-2 infection.

Updated vaccines could curb transmission 

Given the likelihood that COVID-19 is sticking around and the realization that infection-preventing immunity generated by the virus and the vaccines wanes, periodic revaccination (like the annual flu shot) may be necessary as we learn how to best live with the virus, Schaffner says. “And maybe we will have to create an updated COVID vaccine the way we create an updated influenza vaccine on an annual basis,” he adds.

COVID-19 vaccine makers are working on a new generation of their products, health officials have confirmed. The hope is that advancements in vaccine technologies — be it a nasal vaccine or a formula that targets more than one variant — could provide even greater protection against infection and reinfection. 

In the meantime, there are steps you can take to reduce your risk of coming down with COVID once, twice or multiple times. These are the same preventive measures that experts have been recommending all along: Stick to well-ventilated spaces, wear a high-quality mask in crowded indoor settings, keep a safe distance from others, and pay attention to the level of transmission in your community. “If there is a surge, the likelihood of being reinfected is much higher than if there is no virus circulating or a lesser amount of virus circulating,” Sette says.

Also, stay up to date with the COVID-19 vaccines, Adalja urges, and “have a plan for rapidly testing yourself and getting linked to treatments like monoclonal antibodies or antivirals if you test positive.” 

Editor's Note: This story, originally published June 1, 2022, has been updated to reflect new information.