St. John’s Wort 101
You may have heard of St. John's wort. Over the centuries, St. John's wort has been used to treat mental disorders and nerve pain. In fact, in ancient times, herbalists wrote about its use as a sedative and a treatment for malaria, as well as a balm for wounds, burns, and insect bites.
Today, some people use St. John's wort for depression, anxiety, and/or sleep disorders. But it is important to know that St. John's wort is not a proven therapy for depression. If depression is not adequately treated, it can become severe. Anyone who may have depression should see a health care provider.
What the Science Says
There is some scientific evidence that St. John's wort is useful for
treating mild to moderate depression. However, two large studies, one sponsored
by the National Center for Complementary and Alternative Medicine (NCCAM),
showed that the herb was no more effective than placebo in treating major
depression of moderate severity.
Side Effects and Cautions
St. John's wort may cause increased sensitivity to sunlight. Other side
effects can include anxiety, dry mouth, dizziness, gastrointestinal symptoms,
fatigue, headache, or sexual dysfunction.
Research shows that St. John's wort interacts with some drugs. The herb affects the way the body processes or breaks down many drugs; in some cases, it may speed or slow a drug's breakdown. Drugs that can be affected include:
- Indinavir and possibly other drugs used to control HIV infection
- Irinotecan and possibly other drugs used to treat cancer
- Cyclosporine, which prevents the body from rejecting transplanted organs
- Digoxin, which strengthens heart muscle contractions
- Warfarin and related anticoagulants
- Birth control pills
- Antidepressants*
*When combined with certain antidepressants, St. John's wort may increase side effects such as nausea, anxiety, headache, and confusion.
Remember: It is important to inform your health care providers about any herbal or dietary supplement you take, including St. John's wort. This helps to ensure safe and coordinated care.
For more information, visit: http://nccam.nih.gov/health/stjohnswort/
Source: National Center for Complementary and Alternative Medicine (NCCAM), National Institutes of Health
