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Are Women Being Overtreated for Bone Loss?

Nancy Hughes, 55, of Alexandria, Va., played tennis and went to the gym regularly, but recently her lower back began to hurt “on and off” after exercising. Hughes made an appointment to have it checked out. In addition to an x-ray, she had a scan that revealed osteopenia, bone density somewhat lower than normal. Her doctor wrote a prescription for a bone-building drug.

Now, she says, “I’m going to do some research, so I can understand what’s happening and decide how to proceed.”

Hughes found herself in a raging debate about osteopenia and how—and if—it should be treated. The condition is common in women after 50 and not as severe as osteoporosis, a bone-weakening disease that can lead to fractures. Women begin losing bone density around age 30, and the risk of osteoporosis increases with age, as the bones become thinner.

Until recently, doctors prescribed bone-strengthening drugs to women as soon as they hit menopause, when they produce less estrogen—a hormone that helps bones stay strong.

But in the last two years, as the Food and Drug Administration began reporting serious side effects of bone-strengthening medications, a number of experts urged caution, warning that many younger postmenopausal women may be taking drugs they don’t need. Instead, the experts recommended giving medication only to those who have confirmed osteoporosis or who fracture a bone for no apparent reason.

For the estimated 8 million women in the United States who have osteoporosis, bone-strengthening medications can lower the chances of breaking a bone. But many experts argue that for women over 50 who have osteopenia, testing and subsequent drug prescriptions may be a waste of time and money.

In spite of recommendations to wait until age 65 to screen healthy women, many younger women undergo bone mineral density testing, which often leads to drug therapy.

“Advertising and promotional activities have frightened people about osteoporosis,” says Gordon Guyatt, M.D., of McMaster University in Hamilton, Ontario. Women have gotten the message that they should be tested early, and the sooner after menopause the better. Yet, Guyatt says, the risk of fracture among younger women is very low.

Testing, treating

When should women be tested? The U.S. Preventive Services Task Force recommends that routine bone density screening start at age 65. It suggests screening women age 60 to 64 with other risk factors—such as low body weight or smoking—but notes that testing healthy women under 60 would prevent few fractures.

Recent guidelines from the National Osteoporosis Foundation (NOF) also recommend screening women without risk factors at age 65—and men at 70. It recommends treating men and women over 50 who have a 3 percent risk of hip fracture over the next 10 years or have a 20 percent risk of fracture of the spine, wrist, hip or upper arm bone over the next 10 years.

The World Health Organization has developed an online tool called FRAX so people can assess their risk of fractures within 10 years. “Osteopenia alone doesn’t mean much,” says Robert Recker, M.D., director of Creighton University’s Osteoporosis Research Center. “What’s more important is the risk of fracture. Having a 10-year projection allows you and your doctor to do some planning.”

An x-ray technique called DXA or DEXA defines how far bone mineral density falls above or below the norm. In this case the norm is an average healthy woman in her 30s. The closer the score is to zero, the better the bone density. A score of -1 or higher is considered normal; -2.5 or lower signifies osteoporosis. Anything between -1 and -2.5 is labeled osteopenia, a term for low bone mass that the WHO coined in the early 1990s.

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