That’s not a problem only for people who don’t want to buy new pants. Abdominal fat can be toxic, says Pamela Peeke, M.D., adjunct assistant professor of family and community medicine at the University of Maryland School of Medicine and author of The Hunger Fix: The Three-Stage Detox and Recovery Plan for Overeating and Food Addiction. Abdominal fat produces hormones and proteins that increase appetite and, potentially, insulin resistance, raising the risk of heart disease and type 2 diabetes.