Four Seasons (Borgo Pinti 99; www.fourseasons.com/florence; tel. 055-2626-250)
There was never really any doubt, when the Palazzo della Gherardesca reopened in 2009 as the Four Seasons Firenze after a 7-year restoration project -- this was destined to be the most luxurious address in Tuscany. Original frescoes on the 15th-century walls, sumptuous decor, and some of the city's finest dining are just a few of the earthly delights you'll find here.

Helvetia & Bristol (Via dei Pescioni 2; www.royaldemeure.com; tel. 055-26-651)
This most central of Florence's luxury addresses was the city's leading hotel in the 19th century, and guest rooms and lounges still exude an opulent turn-of-the-20th-century air. The bright and refreshing small Winter Garden bar, with trailing ivy and a splashing fountain, doubles as the breakfast room. The location, opposite the Strozzi and a few paces from Via de' Tornabuoni, could hardly be better for a shopping- and culture-fueled visit.

Residence Hilda (Via dei Servi 40; www.residencehilda.it; tel. 055-288-021)
Step off the Renaissance square of Santissima Annunziata right into the 21st century at this apartment building, where clean, contemporary design is complemented by high-quality modern conveniences. Add hotel amenities to those cool, airy spaces, stripped-wood floors, and cream walls and fabrics, then throw in a management team who can't do enough to help you out, and you have just about the perfect Florence accommodation package. Oh, and did we mention it's just 2 blocks from the Duomo?