6. Overseas Highway, Fla.
U.S. Route 1 takes you 127.5 miles from the southern tip of Florida to the end of the road — and the land — at Key West. On the way, you'll cross the aptly named Seven Mile Bridge, spanning Knight's Key in the Middle Keys to Little Duck Key in the Lower Keys.
7. Vermont Route 100
In winter, it's known as the Skier's Highway, accessing Stowe, Mount Snow and Okemo, and in fall it's the favored road to see the colors change in spectacular fashion. But in summer, the 200-mile highway running up Vermont's spine is still one of the best places to cruise in New England, passing pine-covered mountains, beautiful lakes and quaint, low-key towns.
8. Teton Park Road and John D. Rockefeller Jr. Parkway, Wyo.
Take your time on this route that passes from the town of Jackson through Bridger-Teton National Forest to Yellowstone National Park: You'll spot a range of wildlife, especially if you venture out at dawn or dusk. It hugs the stunning Tetons, with countless points to pull over for foolproof photo ops.
9. North Cascades Highway, Wash.
This road was once a Native American trading route and now is part of a 400-mile loop through the North Cascades, often called America's Alps. It's known for avalanches in the winter, but in summer it's a nature lover's haven. Bed down in Winthrop, a picture-perfect town, and drive Cascade River Road from Marblemount for a worthy detour.