Excessive gas

 | January 1, 2008

Excessive gas

Aside from causing embarrassment, too much gas in the digestive system can result in considerable pain, bloating, and discomfort — symptoms that may appear on their own or in conjunction with functional dyspepsia or irritable bowel syndrome. Sometimes, you may even hear and feel air and liquid swirling around inside. But there are practical steps you can take to control this problem.

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Where does gas come from?

There are only two ways for gas to get into the GI tract. Either you swallow it (aerophagia), or it's manufactured in the gut (often producing flatus).

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Aerophagia

Aerophagia — excessive swallowing of air — produces belching or burping. The upper gastrointestinal gas that erupts from the mouth comes from swallowed air that forces itself back up. There are actually two kinds of belching. One is a fairly innocuous condition that stops on its own about an hour after eating and is caused by air swallowed while eating. The other is more persistent and is caused by constant air swallowing, a nervous habit most people don't even know they have.

Technically called eructation, belching occurs when the upper esophageal sphincter relaxes and lets the pressurized gas that has been swallowed escape from the mouth. A study has found that healthy young people belch an average of 11 times in 20 hours, excluding mealtimes.

Do you have aerophagia?

According to the Rome III criteria, for a diagnosis of aerophagia, patients must have experienced both of the following for the past three months, with symptoms starting at least six months before diagnosis:

troublesome repetitive belching at least several times a week

air swallowing that is objectively observed or measured.

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Flatus

Also known as flatulence, this term describes gas that escapes from the rectum. The gas is mostly the byproduct of the fermentation of undigested food by bacteria in the colon. It contains carbon dioxide, hydrogen, and, in some people, methane. Tiny amounts of volatile chemicals produced by bacterial metabolism of residual fats and proteins are responsible for the distinctive foul odor of flatus.

Gas that escapes from the far end of the GI tract may be natural, but nowhere is it an accepted part of society. The average human intestine holds 0.1 to 0.2 liters of gas, but researchers have found that in 24 hours, production of flatus averages 2 liters. This gas originates in the intestine, and its quantity and composition depend largely on the foods you eat. Studies using hydrogen breath testing have found that up to one-fifth of the complex carbohydrates eaten by average, healthy individuals is turned into gas.

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A gas primer

The air we breathe is made up mostly of nitrogen (N2 ) and oxygen (O2 ), the gas the human body needs to sustain life. After being swallowed, air enters the GI tract. As it moves along, its makeup changes as oxygen passes into the blood and nitrogen is removed from the blood. Another intestinal gas is carbon dioxide (CO2 ), a byproduct of a chemical reaction with acid in the stomach. Hydrogen (H2 ) is released in the colon when undigested carbohydrates undergo bacterial fermentation.

Bacteria in the gut produce foul-smelling gases when they ferment undigested foods that have not been absorbed in the small intestine. These foods consist mostly of carbohydrates, sugars, and fats. The carbohydrates found in high-fiber foods, such as beans, broccoli, cauliflower, and Brussels sprouts, are the worst culprits. These foods release gases such as methane and hydrogen sulfate, which smells like rotten eggs. The worst odor is related to strong-smelling sulfurs that make up just 1% of flatus.

Methane is detected in about one-third of adults. Studies show that Americans and Europeans are more likely to produce methane than Asians are, possibly because of diet. Women also produce more than men do. Genes may play a role in methane production, as the trait is passed along in families.

Additional carbon dioxide is produced in the colon as the byproduct of bacterial fermentation of unabsorbed sugars and starches. Eating beans will substantially increase CO2 production, as will taking sodium bicarbonate for heartburn. Thus, it doesn't make sense to use bicarbonate-containing seltzers for gas.

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Gas in the intestine

You hardly notice gas when it enters your digestive system, but once it's there, the discomfort can be intense. As for its escape, everyone knows the effect created by powerful gaseous emissions.

People who suffer the symptoms of gas pain and bloating usually have the same volume of gas as anyone else, or just a little bit more. But it affects them more because they are more sensitive. Some people with chronic gas pain have impaired peristalsis and significant reflux of gas from the small intestine into the stomach.

Although gas pain and bloating are usually not significant health concerns, it is important to see a doctor if the symptoms persist because they are occasionally a sign of some more serious condition. Severe distension immediately following a meal is called magenblase (stomach bubble) syndrome and may be mistaken for heart pain. Splenic flexure syndrome is a painful spasm in the left upper abdomen below the rib cage, produced by localized areas of trapped gas in the colon.

Borborygmi is an onomatopoeic word that refers to sounds created by peristaltic activity. Although disconcerting to the person whose insides are grumbling, it often goes unnoticed by anyone else.

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Eating habits and gas

Throughout history, certain foods have been notorious for producing gas (see "Foods that may cause gas"). Beans are the most obvious example. Beans contain the complex carbohydrates stachyose and raffinose, which the intestine can't absorb but the bacteria in the colon love. The problem is most serious in people who have been eating a low-fiber diet and switch to a diet rich in beans and other high-fiber foods. Their digestive tracts don't have enough of the enzymes needed to digest bean sugars, which now pass undigested into the lower intestine where the bacteria metabolize them and generate gas. If people eat beans on a regular basis, the problem usually lessens as the body begins to produce the enzymes it needs.

People who are lactose intolerant often describe distressing flatulence if they consume milk products (see "Understanding food intolerance"). Other factors, such as disturbances in motility or metabolism, also influence how often and how much flatus is passed. For instance, people with slowed intestinal motility may produce more gas simply because bacteria have more time to work their magic on complex carbohydrates. Gas production may also increase when people take antibiotics, which lead to changes in the types of bacteria in the colon, or when the acidity level in the bowel goes down.

Foods that may cause gas

There is great variation in the foods that cause gas in different people. Some of the more common offenders are listed below.

Apples

Bananas

Beans, peas, and lentils

Broccoli

Brussels sprouts

Cabbage

Carbonated beverages

Cauliflower

Corn

Cucumbers

Grapes

Milk and other dairy products

Nuts

Oats and other high-fiber foods

Onions

Raisins

Sorbitol

Turnips

Wine

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Diagnosing and treating aerophagia and flatus

The important thing for a doctor to consider in diagnosing a belching, bloating, or flatulence problem is whether it's occurring alone or in conjunction with one or more of the various functional GI disorders or a more serious GI illness. He or she should be alert to problems that may suggest organic disease, such as weight loss or anemia. Of course, a physician may be able to determine quickly that the problem is the result of eating too many beans or swallowing too much air. In most cases, evaluating complaints of gassiness will not require extensive diagnostic testing.

To assess your gassiness, your doctor will first question you about your symptoms and dietary patterns. If upper GI bloating and belching are the major problems, excessive air swallowing may be the culprit. The doctor will ask about possible lactose intolerance as well as habits such as gulping down meals, drinking carbonated beverages, sipping through a straw, chewing gum, smoking cigarettes, or chewing tobacco.

The doctor will also want to know about anxiety and psychological problems that may contribute to air swallowing and predispose people to symptoms, including gas and cramping. Likewise, he or she will want to review the medications you are taking, since some — especially drugs that are encapsulated with a sorbitol filler — can induce gas, bloating, and diarrhea.

An abdomen distended with air can be detected by listening for a hollow sound when tapped. Organic causes of intestinal distension include obstruction of the bowel or fluid or a mass in the abdomen. But other signs usually accompany these more serious problems, and they usually can be readily confirmed by an imaging study such as a CT scan. Some, such as gastric distension, can be identified with a simple abdominal x-ray. Some doctors may want to run a lactose absorption test or hydrogen breath test to check for lactose intolerance.

Bloating and distension: It's not just excess gas

Your abdomen feels uncomfortably full and actually looks a bit larger than usual. Is it just excess gas? That may be part of the explanation, but it's unlikely to be the whole story.

That feeling of fullness and tightness in the abdomen is called bloating, while distension is the actual stretching of the abdomen. The two conditions usually occur together, but it is possible to have bloating without distension. Bloating with distension, however, is much more bothersome than bloating alone.

Bloating affects 10% to 30% of the general population, with women twice as likely to experience it as men. Functional bloating is an independent diagnosis, but it is also frequently associated with other functional gastrointestinal disorders. For example, 75% of IBS patients complain of bloating; in fact, IBS patients often rank bloating as their most bothersome symptom. Bloating is also often accompanied by excessive flatulence and frequent belching.

You might think that bloating and distension would be due to excess gas. But excess gas is not likely to be the only cause of abdominal distension. Here's a case in point: in order to distend the gut by just 2 centimeters, the abdomen must contain 10 times as much gas as normal. In IBS patients, the abdomen distends by an average of 12 centimeters in one day — that would mean at least 60 times as much gas as normally would be present if excess gas alone were to blame.

So what causes bloating and distension? There is some evidence to suggest that the way the intestine handles gas is impaired in people with bloating and distension. Abdominal wall strength or function may also play a role. For example, abdominal muscles relax during meals to accommodate large volumes of food. In distended patients, the abdominal wall may relax to an abnormally exaggerated degree. Excessive descent of the muscles of the diaphragm, which separates the chest from the abdominal cavity, may also play a role.

There are no surefire treatments for bloating and distension. Gradually decreasing the amount of wheat fiber in the diet may reduce symptoms. Use of alpha-galactosidase (Beano), charcoal (which absorbs gas), and simethicone (Gas-X, Phazyme, Mylicon) are not backed by solid evidence, but these products may work, and they are generally considered to be safe. Probiotics have had some success in clinical trials. And in one well-designed study, a 10-day course of the antibiotic rifaximin significantly improved the discomfort of bloating compared with placebo.

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Treating belching

The key here is to reduce the amount of air you swallow. Quitting chewing gum and smoking — and maybe trading in loose dentures for snugger ones — should cut down on air gulping. One easy fix is to avoid carbonated drinks and whipped desserts, which trigger burping. Some people swear by including certain foods in the diet, such as brown rice or barley broth. Papaya and pineapple are also said to help. Make sure to chew foods slowly, avoid washing food down with liquids, and try to eat smaller meals. And don't eat when you are anxious, upset, or overtired. If you have aerophagia, antidepressants and tranquilizers may calm the nerves or lessen anxiety, but they must be used carefully and only under a doctor's close supervision.

Taking a brisk stroll after eating, rather than taking a nap, is a good idea. It promotes gastric emptying and helps relieve the bloated feeling. When it's time to go to bed, try sleeping on your stomach or right side to aid in the escape of gas and alleviate fullness.

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Treating flatulence

The first step is easy. Stop eating the foods that cause gas: beans, fruits, and other complex carbohydrates, as well as the artificial sweetener sorbitol. But don't eliminate all fruits and vegetables, because these foods are the basis of a healthy diet. A product called Beano, which contains the enzyme alpha-galactosidase, can help metabolize difficult-to-digest complex carbohydrates when taken before meals. And preparations containing the pancreatic enzymes lipase, trypsin, and amylase may reduce gassy emissions by helping to digest proteins, starches, and fats when taken with meals. These enzymes are sold over the counter in capsule form (a product called Super Digestive Enzymes is one example), at stores that sell nutritional supplements.

For some people, a drastic reduction in dietary sugars and some cutback in refined starches and wheat flour may help. Activated charcoal, a tasteless black powder, absorbs gas and for some people cuts down on gassiness, particularly after a high-carbohydrate meal. Occasional use is not harmful. Pepto-Bismol may reduce the odor of flatus.

Some people have had success with anticholinergics, drugs such as dicyclomine (Bentyl) and hyoscyamine (Levsin). These agents block nerves that stimulate the digestive tract. A course of the broad-spectrum antibiotic rifaximin (Xifaxan) may also help reduce flatulence, without side effects.

When all else fails, wearing a deodorizing and absorbing pad containing activated charcoal beneath one's undergarments doesn't stop flatulence, but it can prevent others from noticing it. A 2005 study in the American Journal of Gastroenterology found that such devices are moderately effective.

Table 2: Drugs used to treat functional gastrointestinal disorders

Pregnant or nursing women should not take these drugs, except on the specific advice of a physician.

Antacids

Active ingredient*

Brand name

Use

Side effects

Comments

alumina, aluminum carbonate, aluminum hydroxide

Amphojel, Gaviscon, Maalox, Mylanta

Relieve heartburn and functional dyspepsia pain, and promote ulcer healing by neutralizing stomach acid

Constipation; diarrhea; excessive and prolonged doses may cause bone pain, feeling of discomfort, appetite loss, mood changes, muscle weakness

Side effects more likely for people with kidney disease; aluminum-containing antacids not advised for elderly people with bone disease or Alzheimer's disease; do not use within three to four hours of taking tetracycline-type antibiotics

calcium carbonate

Alka-Mints, Caltrate, Rolaids, Tums

Chalky taste; constipation; excessive and prolonged doses may cause difficult, painful, or frequent urination, appetite loss, mood changes, muscle pain or twitching, nausea, restlessness, unpleasant taste

Side effects more likely for people with kidney disease

magnesia, magnesium carbonate, magnesium hydroxide, magnesium trisilicate

Gaviscon, Gelusil, Maalox, Mylanta, Phillips' Milk of Magnesia

Chalky taste; excessive and prolonged doses may cause difficult or painful urination, dizziness, irregular heartbeat, loss of appetite, mood changes, muscle weakness

Side effects more likely for people with kidney disease; do not use within three to four hours of taking tetracycline-type antibiotics

sodium bicarbonate

Alka-Seltzer, baking soda

Abdominal fullness; belching; excessive and prolonged doses may cause frequent urge to urinate, mood changes, muscle pain, nausea, restlessness

Not advisable for people on low-sodium diets; side effects more likely for people with kidney disease

*Most over-the-counter antacids contain two or more of these active ingredients.

Anticholinergics/Antispasmodics

Generic name

Brand name

Use

Side effects

Comments

atropine with hyoscyamine and phenobarbital

Arco-Lase Plus

Relieve gastrointestinal cramps, spasms

Dry mouth, difficulty urinating or urinary retention, blurred vision, rapid heartbeat, increased ocular tension, headache, nervousness, drowsiness; antispasmodics that contain phenobarbital may cause sedation, drowsiness, or, rarely, agitation

Should not be used by people with glaucoma; a physician should be consulted about concurrent use because these drugs block or boost the actions of many other medications; phenobarbital may decrease the effect of anticoagulants and may be habit-forming

atropine with hyoscyamine, phenobarbital, and scopolamine

Donnatal

dicyclomine

Bentyl

hyoscyamine

Levsin

Antidiarrheal agents

Generic name

Brand name

Use

Side effects

Comments

diphenoxylate and atropine

Lomotil, Logen

Stop diarrhea by slowing down intestinal movement

Abdominal discomfort; constipation; less frequently, may cause blurred vision, urinary discomfort, dry mouth or skin, rapid heartbeat, restlessness, or warm, flushed skin

Drink plenty of fluids; may be habit-forming; not to be used with alcohol or other depressants

loperamide

Imodium, Imodium A-D

Reduce secretion of fluid by the intestine

Abdominal discomfort; constipation; less frequently, may cause drowsiness, dizziness, dry mouth, nausea, vomiting, rash

Drink plenty of fluids; should be used with caution by people with liver disease

Chloride channel activator

Generic name

Brand name

Use

Side effects

Comments

lubiprostone

Amitiza

Relief of constipation-dominated IBS

Nausea, diarrhea, abdominal pain; rarely, urinary tract infections, dry mouth, fainting and swelling, difficulty breathing, and heart palpitations

 

Histamine H2 -receptor antagonists

Generic name

Brand name

Use

Side effects

Comments

cimetidine

Tagamet

Relieve heartburn and functional dyspepsia pain and promote ulcer healing by decreasing stomach acid

Rarely, may cause diarrhea, constipation, dizziness, anxiety, depression, drowsiness, sleeplessness, headache, irregular heartbeat, increased sweating, burning, itching, redness of skin, fever, confusion in ill or elderly people

May interfere with the absorption of anticoagulants, antidepressants, and hypertension medications

famotidine

Pepcid

No serious drug interactions known

nizatidine

Axid

ranitidine

Zantac

At high doses may interact with anticoagulants

Laxatives

Generic name

Brand name

Use

Side effects

Comments

docusate

Colace, Surfak

Soften stool by merging with feces and softening consistency

Stomach or intestinal cramps, stomach upset, throat irritation

Generally considered safe for long-term use

mineral oil

various

Soften stool by merging with feces and softening consistency

May cause deficiencies of fat-soluble vitamins if used regularly; can cause lung damage if accidentally inhaled

 

polyethylene glycol

Miralax

Soften stool and increase the number of bowel movements by flushing the intestine

Upset stomach, bloating, cramping, gas

Considered safe for use during pregnancy

bisacodyl

Correctol, Dulcolax, Fleet, others

Increase the motility of the bowel

Stomach cramps, upset stomach, diarrhea, stomach and intestinal irritation, faintness, irritation or burning in the rectum (from suppositories)

May lead to dependency, have diminished effects with long-term daily use, or cause bowels to lose their normal ability; best used for occasional constipation; may cause a blackening of the lining of the colon seen on colonoscopy, which appears to be harmless

castor oil

Castor oil, Purge

Cause fluid to accumulate in the small intestine

Diarrhea, upset stomach, vomiting, irritation, stomach cramping

 

senna

Ex-Lax, Fletcher's Castoria, Senokot, others

Increase motility of the bowel

Diarrhea, upset stomach, vomiting, irritation, stomach cramping, pseudomelanosis coli

 

lubiprostone

Amitiza

Increase the amount of fluid secreted into the bowel, allowing stool to pass more easily

Nausea, diarrhea, bloating, stomach pain, gas, vomiting, heartburn, dry mouth, headache

May be a good option for those not helped by standard treatments

Prokinetic agents

Generic name

Brand name

Use

Side effects

Comments

metoclopramide

Reglan

Enhance gastric emptying

Diarrhea; less frequently, may cause involuntary movement of limbs, restlessness, drowsiness, muscle tremor, spasms, breast discharge

Increases the effects of alcohol and other depressants; caution advised for patients with type 1 diabetes or Parkinson's disease

Proton pump inhibitors

Generic name

Brand name

Use

Side effects

Comments

lansoprazole

Prevacid

Treat reflux esophagitis and promote peptic ulcer healing by suppressing secretion of stomach acid

Rarely, may cause diarrhea, abdominal pain, nausea

May speed the elimination of theophylline; also available as an IV formulation

omeprazole

Prilosec, Zegerid

Rarely, may cause constipation, chest pain, headache, gas, rash, drowsiness

May prolong the effect of other prescription drugs, including diazepam, warfarin, and phenytoin

rabeprazole

Aciphex

pantoprazole

Protonix

Also available as IV formulations

esomeprazole

Nexium

Selective serotonin reuptake inhibitors (SSRIs)

Generic name

Brand name

Use

Side effects

Comments

citalopram

Celexa

Relieve chronic abdominal pain

Upset stomach, diarrhea, vomiting, stomach pain, drowsiness, excessive tiredness, tremor, excitement, nervousness, difficulty falling or staying asleep, muscle or joint pain, dry mouth, excessive sweating, changes in sex drive or ability, loss of appetite

Limited experience in functional bowel disorders. May help close the pain gate in some people.

fluoxetine

Prozac

Rash, headache, dizziness, insomnia, anxiety, drowsiness, excessive sweating, nausea, diarrhea, bronchitis, weight loss, painful menstruation, sexual dysfunction, urinary tract infection, chills, muscle or joint pain, back pain

paroxetine

Paxil

Pain, bodily discomfort, hypertension, sudden loss of strength, rapid heartbeat, itching, nausea, vomiting, weight gain or loss, central nervous system stimulation, depression, vertigo, cough

sertraline

Zoloft

Nausea, trouble sleeping, diarrhea, dry mouth, sexual dysfunction, drowsiness, tremor, indigestion, increased sweating, increased irritability or anxiety, decreased appetite

Serotonin agonists/antagonists

Generic name

Brand name

Use

Side effects

Comments

alosetron

Lotronex

Reduces cramping, abdominal pain, urgency, and diarrhea caused by IBS

Constipation; in rare cases, may cause diarrhea and intestinal bleeding

Available only under a tightly controlled program; only proven effective for women

tegaserod

Zelnorm

Decreases abdominal pain, bloating and constipation caused by IBS; relieve chronic constipation with no known cause

Diarrhea; stomach pain; increased risk of heart attack, stroke, and unstable angina

Available only on a severely restricted basis to women with irritable bowel syndrome or functional constipation who are in critical need of the drug; women must be younger than age 55 and have no pre-existing heart problems

Tricyclic antidepressants

Generic name

Brand name

Use

Side effects

Comments

amitriptyline

Elavil, Endep

Relieve chronic abdominal pain

Dizziness, dry mouth, blurred vision, drowsiness, constipation, urinary retention, hypotension, cardiac arrhythmia

Should not be used with alcohol, other antidepressants, or immediately following a heart attack; side effects may be worse when cimetidine is used simultaneously; caution advised for patients with glaucoma; used at lower doses than for the treatment of depression

desipramine

Norpramine

nortriptyline

Pamelor

Other agents

Generic name

Brand name

Use

Side effects

Comments

activated charcoal

Actidose-Aqua, CharcoCaps

Relieve intestinal gas

Black stools, abdominal pain

Effectiveness uncertain; do not take at the same time as other medications

alpha-galactosidase

Beano

Reduces intestinal gas by breaking down indigestible carbohydrates into digestible sugars

No known side effects

Effectiveness uncertain

bismuth subsalicylate

Pepto-Bismol

Relieves heartburn, indigestion, nausea, diarrhea; occasionally used with antibiotics to cure ulcers

Dark tongue, grayish-black stools; excessive doses may cause anxiety, constipation, dizziness

Avoid if allergic to aspirin or other salicylates

lactase

Lactaid

Relieves gas, abdominal bloating, and diarrhea by breaking down milk sugar into simpler forms that can be absorbed into the bloodstream

No known side effects

Effectiveness uncertain; available as pills or prepared products

rifaximin

Xifaxan

Prevents traveler's diarrhea caused by E. coli; treats small intestine bacterial overgrowth in some IBS patients; reduces flatulence and discomfort of bloating

Headache, constipation, hives and itchiness

Should not be used by people with fever or blood in stool

simethicone

Gas Relief, Gas-X, Mylanta Gas, Phazyme

Relieve pain from excess gas

No known side effects

Effectiveness uncertain

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Review Date: 2008-01-01

Harvard Medical School does not endorse products or services.

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