KELSEY GRAMMER, 56: Another alum of Cheers (and Frasier), Grammer is going the dark dramatic route this fall with Boss on the cable channel Starz. He plays a ruthless, manipulative Chicago mayor with a secret: only he and his doctor know that he has a degenerative brain disease. Grammer says working on the show is "the greatest time of my life creatively."
DYLAN MCDERMOTT, 49: McDermott shows us just how sexy a man of 50 can be (he turns the big 5-0 on Oct. 26) in FX's risky American Horror Story. It's a drama in which he and Connie Britton (Friday Night Lights) play a troubled couple who move with their family into a highly haunted house in L.A. Creators Ryan Murphy and Brad Falchuk (Glee, Nip/Tuck) call their breathtakingly paced show a psycho-sexual drama about marriage and infidelity.