Meg Ryan Turns 50

The Big 5-Oh: November 19

“I have to be on my toes around Meg,” Tom Hanks told an interviewer. “It's like a great tennis match...she makes me better.”

See also: Obama's 50th birthday wish.

Since nuzzling with Hanks in You've Got Mail (1998), Ryan has been on-screen less often — partly due to Hollywood's insistence that she remain Our Lady of Perpetual Perkiness. But she's shown depth in films like In the Land of Women (2007). She's a doting mom to Jack, 19 (with ex-hubby Dennis Quaid), and Daisy True (adopted in 2006), has a new man (rocker John Mellencamp), and is directing her first film, Into the Beautiful. Plus, she's still darned perky. 

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